Docteur Philippe Gris
Publications

 

P.GRIS,  I.PERLOT,  A.FLEMALE,  J.P.DELMEZ,  J.P.DIERCKX.  Coxsackie B3 virus infection, an unusual cause of mediastinal nodal enlargement. Respiration 1988; 53:246-250.

P.GRIS,  P.BURTON.  La Zidovudine dans le traitement du Sida : premier bilan te perspectives. Abstract 1987; 16:8-11.

P.GRIS.  Eicosanoides, éosinophiles, médiateurs des réactions  inflammatoires et allergiques.  Abstract  1988; 23:11-14.

P.GRIS,  M.COFFERNILS,  T.ALAME,  T.P.KIMBIMBI.  Intoxication volontaire par Verapamil,  à propos d’un cas, revue de la littérature.  Sem. Hôp. Paris  1989; 65:435-438.

P.GRIS,  P.DUCHATELET,  J.P.DIERCKX,  H.DEMOL,  A.QUOIDBACH,  E.DUPONT.  Pleural fluid in Wegener’s granulomatosis  (letter). Chest 1989; 96:224.

P.GRIS,  G.VINCKE,  J.P.DELMEZ,  J.P.DIERCKX.  Neisseria Sicca pneumonia and bronchiectasis. Eur. Respir. J. 1989; 2:685-687.

P.GRIS,  M.COFFERNILS,  M.LEON,  C.REUSE,  J.L.VINCENT.  Right ventricular dysfunction in patient with septic shock. Resuscitation 1989  (in press).

T.ALAME,  A.DEWEWEIRE,  P.GRIS,  M.COFFERNILS,  B. VAN DEN HEULE,  J.P.DELMEZ,  E.LONGEVAL.  Réaction leucémoïde et hypercalcémie au cours d’un adénocarcinome de la vessie.  Rev. Méd. Brux. 1990; 11:59-62.

P.GRIS,  Y.PIRSON,  J.HAMELS,  J.P.VAERMAN,  A.QUOIDBACH,  H.DEMOL.  Anti-glomerular basement membrane nephritis induced by IgA1 antibodies. Nephron 1991; 58:418-424.

J.BAKKER,  M.COFFERNILS,  M.LEON,  P.GRIS,  J.L.VINCENT.  Blood lactate levels are superior to oxygen derived variables in predicting outcome in human septic shock .  Chest 1991; 99:956-962.

P.GRIS.  Déficit en Alpha-1- Antitrypsine: données actuelles .  Best of Pneumology 1991; 1:8-9.

P.GRIS.  Corticoïdes dans la maladie obstructive: quelle voie d’administration ? . Best of Pneumology 1991; 3:9-10.

P.GRIS. Les infections respiratoires basses en pratique. Medisearch 1992; 58:31-35.

J.BAKKER,  J.L.VINCENT,  P.GRIS, , M.LEON,  M.COFFERNILS,  R.J.KAHN.  Veno-arterial carbon dioxide gradient in human septic shock.  Chest 1992; 101:509-515.

J.L.VINCENT,  P.GRIS,  M.COFFERNILS,  M.LEON,  M.PINSKY,  C.REUSE,  R.J.KAHN. Myocardial depression characterizes the fatal course of septic shock. Surgery 1992; 111:660-667.

P.GRIS.  Asthme et grossesse. Best of Pneumology 1992; 5:15-19.

D.LEDUC,  P.GRIS,  P.LHEUREUX,  P.A.GEVENOIS,  P.DE VUYST,  J.C.YERNAULT.  Acute and long term respiratory damage following inhalation of ammonia. Thorax 1992; 47:755-757.

P.GRIS,  E.PANOPOULOS,  M.DE JONGHE.  La vieille dame toussait depuis longtemps (Trachéobronchopathie Ostéochondroblastique). Actualité Médicale Belge  (A.M.B.) 1993; 402: 10 et 13.

P.GRIS. Comparaison d’un traitement bronchodilatateur avec ou sans corticostéroides inhalés dans les maladies obstructives des voies aériennes. Best of Pneumology 1993;8:7-9.

P.GRIS.  Quels sont les patients qui peuvent bénéficier d’une oxygénothérapie chronique à domicile?. Best of Pneumology 1993;8:17-18.

P.GRIS,  B.WILMET,  D.TACK. Quelle était la cause de ces pneumonies à répétition ?  Actualité Médicale Belge (A.M.B.)  1994; 419:11.

P.GRIS. Quel traitement pour quel type d’asthme ?  Best of Pneumology (Special Pharmacists) 1994; Sept.:8-9.

P.GRIS,  B.WILMET,  A.BENCHILLAL,  D.TACK,  D.WERY,  M.DE JONGHE,  C.GILLARD.  Veine cave supérieure gauche persistante. A propos de deux observations. Rev. de Pneumol. Clin. 1995; 51:33-35.

P.GRIS.  Antibiothérapie : critères de choix .  Le Monde Médical  1995; 295: 18-19.

P.GRIS.  Once-daily, 3-day azithromycin  versus a three times-daily, 10-day course of co-amoxiclav in the treatment of adults with lower respiratory tract infections: results of a randomized, double-blind comparative study.  Journal of  Antimicrobial Chemotherapy  1996; 37, Suppl.C : 93-101.

P.GRIS. Qualité de vie du patient asthmatique...Optimale ?. Best of  Pneumology 1996; 15: 10-11.

J.BAKKER, P.GRIS, M.COFFERNILS, RJ.KAHN, JL.VINCENT. Blood lactate levels can predict the development of multiple organ failure following septic shock. Am. J. Surg.1996; 171: 221-226.

P.GRIS.  La toux, un symptôme bien mystérieux. Medical News 1997; 14 : 23-29.

C.DECOSTER, P.GRIS. Comparaison du flixotide haute dose via aérosol doseur et budesonide suspension chez l’adulte asthmatique. Best of  Respiratory 1997 ; 16 : 10-12.

D.TACK, J .JAUCOT, P. GRIS, C. DELCOUR.  Left azygos continuation. Radiological Documents 1997; 11: 1-3.

P.GRIS. Infections respiratoires bactériennes post viroses. Infectiologics, décembre 1997 : 19-20.

P.GRIS. Le pneumocoque fait de la résistance. Medical News 1997 ;22 :31-33.

P.GRIS, A.BAULER. Le Salbutamol en salle d’urgence. Best of  Respiratory 1997 ;18 :6-7.

P.GRIS, D.VOGELAERS. Les anaérobies. Quid Infectio 1998 ;3 :1-3.

P.GRIS, P.VERVACKE. Pneumocoque et mycoplasme, un diagnostic parfois difficile. Cahier Cas Clinique Medical News, avril 1998 :2-4.

D.TACK, L.LENAERTS, P.GRIS, C.DELCOUR. Barotrauma. Radiological Documents 1998 ;3 :1-3.

P.GRIS.  Salmeterol et BPCO. Best of Respiratory 1998 ;19 :7-8.

D.TACK, P.GRIS, C.DECOSTER, C.DELCOUR. Masse thoracique asymptomatique. Rev. Mal. Respir.1998 ,15 :309-311.

P.GRIS, D.TACK, C.GILLARD, J.THIRIAUX. Right tracheal bronchus. Clin. Pulmon. Med. 1998 ;5 :200-201.

A.BAULER, D.TACK, P.GRIS. Aspergillose semi-invasive : cas clinique et revue de la littérature. Astra Respiratory Journal 1998 ;2 :6-11.

P. GRIS.Traitement et prophylaxie de la tuberculose. Bulletin de la Société Clinique du CHU de Charleroi.1998 ;4 : 169-173.

D. TACK, J. JAUCOT , P. GRIS, C. DELCOUR. Anomaly of the vena cava.  JBR-TBR 1999; 82: 125.

P. GRIS. Pneumocoque  et voies aériennes.  Medibytes 2000 ; 5 : 12 – 13.

P. GRIS . Les infections du site chirurgical. Vaisseaux, Cœur, Poumons 2000 ; 5 : 138-140.

D. TACK, LENAERTS L, P. GRIS,  DELCOURT C. Pulmonary interstitial gas. JBR-BTR 2000 ; 83:25.

P.  GRIS .  Antibiothérapie :  traitement long, traitement court ?  Tempo Médical  2002 ; 230 : 44 – 45.
Chest, Vol 101, 509-515, Copyright © 1992 by American College of Chest Physicians www.chestjournal.org

Veno-arterial carbon dioxide gradient in human septic shock

J Bakker, JL Vincent, P Gris, M Leon, M Coffernils and RJ Kahn
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium.

Recent reports have shown that venous hypercarbia, resulting in a widening of the veno-arterial difference in PCO2 (dPCO2), is related to systemic hypoperfusion in various forms of low-flow state. Although septic shock usually is a hyperdynamic state, other factors can influence the CO2 production and elimination, and thus dPCO2 in septic shock This study examined the dPCO2 and acid-base balance together with cardiac output measurements and oxygen-derived variables in 64 adult patients with documented septic shock. For a total of 191 observations, a significant exponential relation between dPCO2 and CO was found. At time of first measurement, 15 patients had an increased dPCO2 (above 6 mm Hg) and a higher mixed venous PCO2 (PvCO2) (47.2 +/- 10.0 vs 35.9 +/- 7.3 mm Hg, p less than 0.001). These patients had a lower cardiac index (2.9 +/- 1.3 vs 3.8 +/- 2.0 L/min.m2, p less than 0.01), a higher oxygen extraction ratio, but a similar VO2 than patients with normal dPCO2. The higher dPCO2 could also be related to an impaired CO2 elimination as indicated by a higher PaCO2 and a lower PaO2/FIO2 in these patients. Nonsurvivors had a significantly higher dPCO2 than survivors (5.9 +/- 3.4 vs 4.4 +/- 2.3 mm Hg, p less than 0.05) in the presence of similar cardiac output. The higher dPCO2 in these patients was probably related to the higher blood lactate levels (7.7 +/- 5.3 mmol/L vs 4.5 +/- 2.8 mmol/L, p less than 0.01) and the more severe pulmonary impairment (SaO2 90 +/- 8 percent vs 95 +/- 4 percent, p less than 0.001). Arteriovenous oxygen content difference (dAVO2) and VO2 were similar in survivors and nonsurvivors. In conclusion, dPCO2 patients with septic shock is related principally to cardiac output but apparently also to the degree of pulmonary impairment. Although dPCO2 is larger in nonsurvivors, its prognostic value is modest.

 

Chest, Vol 99, 956-962, Copyright © 1991 by American College of Chest Physicians www.chestjournal.org

Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock

J Bakker, M Coffernils, M Leon, P Gris and JL Vincent
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium.

Recent reports have shown that oxygen delivery (Do2) and oxygen uptake (Vo2) could be related to outcome of critically ill patients. In this study, we examined measurements of cardiac output, oxygen-derived variables, and blood lactate levels in 48 patients with documented septic shock. There were 27 survivors and 21 nonsurvivors from the shock episode. For all 174 observations, there was a significant linear relationship between Vo2 and Do2 (Vo2 = 79 + 0.17 x Do2, r = 0.64, p less than 0.001). There were no significant differences in Do2 between survivors and nonsurvivors at the onset of septic shock (mean +/- SD, 540 +/- 219 vs 484 +/- 222 ml/min.m2, NS) or in the final phase of septic shock (506 +/- 163 vs 443 +/- 187 ml/min.m2, NS). Also, no significant differences were found in Vo2 and oxygen extraction between survivors and nonsurvivors. However, survivors had significantly lower blood lactate levels both initially (5.1 +/- 2.7 vs 8.2 +/- 5.4 mmol/L, p less than 0.05) and in the final phase of septic shock (2.6 +/- 1.9 vs 7.7 +/- 5.6 mmol/L, p less than 0.001). Only the survivors had a significant decrease in blood lactate levels during the course of septic shock (p less than 0.001). We conclude that the oxygen-derived variables, Do2 and Vo2, cannot be used as prognostic indicators in human septic shock. In contrast, blood lactate levels are closely related to ultimate survival from septic shock. Furthermore, decreases in blood lactate levels during the course of septic shock could indicate a favorable outcome. Therefore, blood lactate levels can serve as a reliable clinical guide to therapy.
 

 
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